Product Information:

CLARITEK XL 500mg Tablets contain Clarithromycin Extended-Release as the active ingredient, a macrolide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. The extended-release (XL) formulation provides once-daily dosing with sustained therapeutic levels over 24 hours, improving patient compliance and maintaining consistent drug exposure. It is effective against Gram-positive, Gram-negative, and atypical bacteria, including Streptococcus pneumoniae, Haemophilus influenzae, Mycoplasma, and Chlamydia species.

Uses of (CLARITEK XL 500MG TABLETS):

1. Treatment of community-acquired pneumonia
2. Management of acute bacterial exacerbations of chronic bronchitis
3. Pharyngitis and tonsillitis caused by Streptococcus pyogenes
4. Skin and soft tissue infections due to susceptible organisms

Key Benefits of (CLARITEK XL 500MG TABLETS):

1. Once-daily dosing enhances treatment adherence
2. Extended-release technology ensures steady drug levels
3. Broad-spectrum activity against respiratory and skin pathogens
4. Acid-stable—can be taken with or without food
5. Reduced gastrointestinal side effects compared to immediate-release forms

How To Use (CLARITEK XL 500MG TABLETS):

Take one tablet once daily with food (to enhance absorption and reduce stomach upset). Swallow whole—do not crush, chew, or split. Complete the full course (typically 7–14 days), even if symptoms improve early, to prevent antibiotic resistance.

When Not to Use (CLARITEK XL 500MG TABLETS):

Do not use if you have:

1. Hypersensitivity to clarithromycin, erythromycin, or other macrolides
2. History of QT prolongation, ventricular arrhythmias, or electrolyte imbalances
3. Concomitant use of cisapride, pimozide, ergotamine, or colchicine (in renal impairment)
4. Severe hepatic dysfunction with concurrent kidney disease

Side Effects of (CLARITEK XL 500MG TABLETS):

Common: Nausea, diarrhea, abdominal discomfort, headache, altered taste.

Serious (rare): QT prolongation, torsades de pointes, hepatotoxicity, severe skin reactions (e.g., Stevens-Johnson syndrome), or Clostridioides difficile-associated colitis. Discontinue and seek medical help if palpitations, jaundice, persistent diarrhea, or rash with blistering occurs.

Dosage: (CLARITEK XL 500MG TABLETS):

1. Standard adult dose: 500mg once daily for 7–14 days
2. Not recommended for H. pylori eradication (use immediate-release form instead)
3. Renal impairment (CrCl <30 mL/min): Avoid or use with extreme caution
4. Always follow your physician’s instructions.

Who It’s For (CLARITEK XL 500MG TABLETS):

Adults and adolescents (≥12 years) with respiratory or skin infections requiring once-daily macrolide therapy. Not suitable for children under 12, neonates, or H. pylori treatment.

Warnings & Precautions:

Use cautiously in patients with liver disease, myasthenia gravis, or cardiac conditions. Avoid in those on other QT-prolonging drugs. Clarithromycin XL is not interchangeable with immediate-release formulations due to different pharmacokinetics.

Drug Interactions:

1. Statins (e.g., simvastatin): ↑ Risk of rhabdomyolysis—avoid combination
2. Warfarin: ↑ INR and bleeding risk—monitor closely
3. CYP3A4 substrates (e.g., carbamazepine, theophylline): ↑ Drug levels
4. Oral hypoglycemics: May potentiate hypoglycemia
5. Always disclose all medications to your doctor.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date on the blister pack. Available by prescription in Pakistan.