Product Information:

CLARITEK 500mg Tablets contain Clarithromycin as the active ingredient, a macrolide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. It demonstrates enhanced activity against a broad spectrum of pathogens, including Gram-positive bacteria (Streptococcus pneumoniae, Staphylococcus aureus), Gram-negative organisms (Haemophilus influenzae), and atypical bacteria (Mycoplasma pneumoniae, Chlamydia, Legionella). This higher-strength formulation is ideal for moderate to severe infections or as part of combination therapy for Helicobacter pylori eradication.

Uses of (CLARITEK 500MG TABLETS):

1. Treatment of community-acquired pneumonia and acute bronchitis
2. Management of pharyngitis, tonsillitis, and sinusitis
3. Skin and soft tissue infections (e.g., cellulitis, abscesses)
4. Helicobacter pylori eradication (in triple therapy with a proton pump inhibitor and amoxicillin/metronidazole)
5. Prevention and treatment of disseminated Mycobacterium avium complex (MAC) in HIV patients

Key Benefits of (CLARITEK 500MG TABLETS):

1. High-potency dose for effective coverage in serious infections
2. Excellent tissue penetration—especially in lungs, skin, and gastric mucosa
3. Twice-daily dosing ensures sustained therapeutic levels
4. Acid-stable—can be taken with or without food
5. Preferred macrolide for H. pylori regimens due to stability and efficacy

How To Use (CLARITEK 500MG TABLETS):

Take exactly as prescribed—typically 500mg every 12 hours for 7–14 days. For H. pylori eradication, it is usually given as 500mg twice daily for 7–14 days alongside a PPI and another antibiotic. Swallow whole with water; do not crush or chew. Complete the full course even if symptoms improve early to prevent resistance.

When Not to Use (CLARITEK 500MG TABLETS):

Do not use if you have:

1. Known hypersensitivity to clarithromycin, erythromycin, or other macrolides
2. History of QT prolongation, ventricular arrhythmias, or electrolyte imbalances
3. Concomitant use of cisapride, pimozide, ergotamine, or colchicine (in renal impairment)
4. Severe hepatic dysfunction combined with renal impairment

Side Effects of (CLARITEK 500MG TABLETS):

Common: Nausea, diarrhea, abdominal discomfort, headache, altered taste (metallic or bitter).

Serious (rare): QT prolongation, torsades de pointes, hepatotoxicity (jaundice, elevated liver enzymes), severe skin reactions (e.g., Stevens-Johnson syndrome), or Clostridioides difficile-associated colitis. Discontinue and seek immediate medical help if palpitations, persistent diarrhea, yellowing of eyes/skin, or rash with blistering occurs.

Dosage: (CLARITEK 500MG TABLETS):

1. Standard infections: 500mg every 12 hours for 7–14 days
2. H. pylori regimen: 500mg twice daily for 7–14 days (with PPI + amoxicillin/metronidazole)
3. Renal impairment (CrCl <30 mL/min): Reduce to 250mg every 12 hours
4. Always follow your physician’s instructions.

Who It’s For (CLARITEK 500MG TABLETS):

Adults and adolescents (≥12 years) with moderate to severe bacterial infections requiring high-dose macrolide therapy. Ideal for respiratory infections, H. pylori treatment, or penicillin-allergic patients. Not for children under 12 or viral illnesses.

Warnings & Precautions:

Use cautiously in patients with liver disease, myasthenia gravis, or cardiac conditions. Clarithromycin may worsen myasthenia symptoms. Avoid in those with baseline QT prolongation or on other QT-prolonging drugs. Monitor liver function during prolonged therapy.

Drug Interactions:

1. Statins (e.g., simvastatin): ↑ Risk of rhabdomyolysis—avoid combination
2. Warfarin: ↑ INR and bleeding risk—monitor closely
3. CYP3A4 substrates (e.g., carbamazepine, theophylline): ↑ Drug levels
4. Oral hypoglycemics: May potentiate hypoglycemia
5. Always disclose all medications to your doctor.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date on the blister pack. Available by prescription in Pakistan.