Product Information:

CIPESTA 200mg/100mL IV Infusion contains Ciprofloxacin as the active ingredient, a broad-spectrum fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, essential enzymes for DNA replication and repair. This ready-to-use intravenous formulation is indicated for the treatment of severe or systemic bacterial infections when oral therapy is not appropriate. It is effective against a wide range of Gram-negative and some Gram-positive organisms, including Pseudomonas aeruginosa.

Uses of (CIPESTA 200MG 100ML IV INFUSION):

1. Treatment of lower respiratory tract infections (e.g., pneumonia)
2. Complicated urinary tract infections (UTIs) and pyelonephritis
3. Intra-abdominal infections (in combination with metronidazole)
4. Skin and soft tissue infections
5. Bone and joint infections
6. Septicemia and febrile neutropenia (as part of empirical therapy)
7. Post-exposure prophylaxis for inhalational anthrax

Key Benefits of (CIPESTA 200MG 100ML IV INFUSION):

1. Ready-to-use premixed infusion—no reconstitution required
2. Rapid bactericidal action against resistant Gram-negative pathogens
3. Excellent tissue penetration, including prostate, lung, and bone
4. Convenient 100mL bag for standardized dosing
5. Suitable for hospital and critical care settings

How To Use (CIPESTA 200MG 100ML IV INFUSION):

Administer by slow intravenous infusion over 60 minutes. Do not administer as rapid IV bolus or IM injection.

1. Usual adult dose: 200mg every 12 hours (range: 200–400mg every 8–12 hours based on infection severity)
2. Duration: Typically 5–14 days, depending on clinical response
3. Complete the full course even if symptoms improve early to prevent resistance.

When Not to Use (CIPESTA 200MG 100ML IV INFUSION):

Do not use in patients with:

1. Known hypersensitivity to ciprofloxacin or other fluoroquinolones
2. History of tendon disorders related to quinolone use
3. Myasthenia gravis (may exacerbate muscle weakness)
4. Pregnancy, breastfeeding, or children/adolescents (<18 years) unless no alternative exists
5. Concomitant use of tizanidine (risk of severe hypotension and sedation)

Side Effects of (CIPESTA 200MG 100ML IV INFUSION):

Common: Nausea, diarrhea, headache, dizziness, injection site reaction.

Serious (rare): Tendonitis/tendon rupture (especially Achilles), peripheral neuropathy, CNS effects (seizures, anxiety, insomnia), QT prolongation, Clostridioides difficile colitis, hepatotoxicity, or photosensitivity. Discontinue immediately if signs of tendon pain, numbness, or severe rash occur.

Dosage: (CIPESTA 200MG 100ML IV INFUSION):

1. Standard dose: 200mg IV every 12 hours
2. Severe infections: May increase to 400mg every 8–12 hours
3. Renal impairment (CrCl <30 mL/min): Reduce dose to 200mg every 24 hours
4. Always individualize therapy based on culture results and organ function.

Who It’s For (CIPESTA 200MG 100ML IV INFUSION):

Hospitalized adults with moderate to severe bacterial infections requiring IV antibiotic therapy. Not for outpatient use, viral infections, or uncomplicated UTIs where safer alternatives exist.

Warnings & Precautions:

Fluoroquinolones carry FDA/EMA black-box warnings for tendon damage, neuropathy, and CNS effects. Avoid in patients with epilepsy, QT prolongation, or electrolyte imbalances. Limit sun exposure due to photosensitivity risk. Monitor renal/hepatic function during prolonged therapy. Reserve for infections with no suitable alternative.

Drug Interactions:

1. Tizanidine: Contraindicated—severe hypotension/sedation
2. Theophylline: Increased levels → risk of seizures
3. Warfarin: Enhanced anticoagulant effect → bleeding risk
4. Antacids, iron, zinc, sucralfate: Reduce absorption—administer CIPESTA ≥2 hours before or 4–6 hours after
5. NSAIDs: May increase CNS stimulation/seizure risk

Additional Information:

Store below 25°C. Protect from light. Do not freeze. Inspect solution before use—discard if cloudy or discolored. Single-use only. Available by prescription only in Pakistan.