Product Information:

CELBEXX 200mg Capsules contain Celecoxib as the active ingredient, a selective cyclooxygenase-2 (COX-2) inhibitor classified as a nonsteroidal anti-inflammatory drug (NSAID). It provides targeted relief from pain and inflammation by blocking the COX-2 enzyme responsible for prostaglandin production at sites of injury or inflammation, while sparing COX-1—which helps protect the stomach lining. This selectivity offers effective symptom control with a significantly reduced risk of gastrointestinal ulcers compared to traditional NSAIDs.

Uses of (CELBEXX 200MG CAPSULES):

1. Management of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis
2. Short-term treatment of acute pain (e.g., dental extraction, post-surgical pain)
3. Relief of primary dysmenorrhea (menstrual cramps)
4. Off-label use in familial adenomatous polyposis under specialist supervision

Key Benefits of (CELBEXX 200MG CAPSULES):

1. Once-daily dosing convenience for chronic conditions
2. Lower risk of gastric irritation, ulcers, and bleeding vs. non-selective NSAIDs
3. Rapid onset of pain relief (within 1–2 hours)
4. Improved safety profile in patients with mild GI sensitivity
5. Effective anti-inflammatory and analgesic action

How To Use (CELBEXX 200MG CAPSULES):

Take exactly as prescribed—typically 200mg once daily or 200mg twice daily depending on the condition. Swallow whole with water, with or without food. Use the lowest effective dose for the shortest duration necessary. Do not exceed 400mg per day. Avoid long-term use without medical review.

When Not to Use (CELBEXX 200MG CAPSULES):

Do not use if you have:

1. Hypersensitivity to celecoxib, sulfonamides, aspirin, or other NSAIDs
2. History of asthma, nasal polyps, or urticaria triggered by NSAIDs
3. Active peptic ulcer disease or gastrointestinal bleeding
4. Severe heart failure, recent CABG surgery, or established ischemic heart disease
5. Pregnancy (especially third trimester)

Side Effects of (CELBEXX 200MG CAPSULES):

Common: Headache, dizziness, abdominal discomfort, nausea, diarrhea, or mild swelling in legs/ankles.

Serious (rare): Heart attack, stroke, severe skin reactions (e.g., Stevens-Johnson syndrome), liver injury (jaundice, dark urine), kidney dysfunction, or GI perforation/bleeding. Discontinue immediately and seek emergency care if chest pain, shortness of breath, black/tarry stools, or yellowing of eyes/skin occurs.

Dosage: (CELBEXX 200MG CAPSULES):

1. Osteoarthritis: 200mg once daily or 100mg twice daily
2. Rheumatoid arthritis: 100–200mg twice daily (max 400mg/day)
3. Acute pain or dysmenorrhea: Initial 400mg, then 200mg as needed (max 400mg/day)
4. Always follow your physician’s prescribed regimen.

Who It’s For (CELBEXX 200MG CAPSULES):

Adults requiring effective, once-daily anti-inflammatory therapy for chronic joint conditions or acute pain, particularly those at higher risk of GI complications with conventional NSAIDs. Not approved for children under 18 or patients with significant cardiovascular disease.

Warnings & Precautions:

Celecoxib may increase the risk of serious cardiovascular and gastrointestinal events, especially with prolonged use or in elderly patients. Use cautiously in those with hypertension, heart failure, renal or hepatic impairment, or history of ulcers. Avoid combining with other NSAIDs or anticoagulants. Monitor blood pressure and kidney function during extended therapy.

Drug Interactions:

1. Aspirin (low-dose): May increase GI risk but often continued for cardioprotection
2. Warfarin: Can elevate INR—monitor closely
3. ACE inhibitors, ARBs, diuretics: Reduced efficacy and increased renal risk
4. Fluconazole: Increases celecoxib levels—dose adjustment may be needed
5. Always inform your doctor about all medications and supplements you are taking.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date printed on the blister pack. Available by prescription only in Pakistan.