Product Information:

CEFOPERZ IV/IM 2000mg is a high-dose sterile powder for injection containing Cefoperazone Sodium, a third-generation cephalosporin antibiotic with extended activity against Gram-negative bacteria, including Pseudomonas aeruginosa, and moderate coverage against Gram-positive organisms. It inhibits bacterial cell wall synthesis and is eliminated via both biliary and renal routes, making it especially useful in hepatobiliary and urinary infections. This 2g formulation is intended for intravenous (IV) or intramuscular (IM) use in moderate to severe systemic infections requiring aggressive parenteral therapy.

Uses of (CEFOPERZ IV/IM 2000 MG):

1. Severe respiratory tract infections (e.g., hospital-acquired pneumonia)
2. Complicated urinary tract infections and pyelonephritis
3. Intra-abdominal infections (e.g., peritonitis, cholangitis)
4. Skin, soft tissue, bone, and joint infections
5. Septicemia and gynecological infections
6. Empirical treatment in febrile neutropenia (often combined with an aminoglycoside)

Key Benefits of (CEFOPERZ IV/IM 2000 MG):

1. High-dose single vial reduces reconstitution steps and administration time
2. Excellent penetration into bile, urine, and inflamed tissues
3. Active against Pseudomonas and other multidrug-resistant Gram-negative pathogens
4. Dual excretion pathway—safe in renal impairment when used alone
5. Suitable for once- or twice-daily dosing in serious infections

How To Use (CEFOPERZ IV/IM 2000 MG):

Reconstitute the vial with appropriate diluent:

1. For IV: Add 10–20 mL of sterile water or 0.9% NaCl; inject slowly over 3–5 minutes or infuse over 30 minutes in 100mL compatible solution.
2. For IM: Reconstitute with 2% lidocaine (without epinephrine) to reduce pain; administer as a deep intramuscular injection.
3. Usual adult dose: 2g every 12 hours (range: 2–4g/day in divided doses), adjusted based on infection severity and organ function.

When Not to Use (CEFOPERZ IV/IM 2000 MG):

Do not use in patients with known hypersensitivity to cefoperazone, other cephalosporins, or penicillins (especially anaphylaxis). Avoid in neonates with hyperbilirubinemia (risk of bilirubin displacement). Contraindicated in patients with active bleeding or significant coagulopathy unless vitamin K is co-administered (cefoperazone may cause hypoprothrombinemia).

Side Effects of (CEFOPERZ IV/IM 2000 MG):

Common: Injection site pain (IM), diarrhea, nausea, rash, transient elevation of liver enzymes.

Serious (rare): Hypoprothrombinemia with bleeding, Clostridioides difficile-associated colitis, anaphylaxis, neutropenia, or eosinophilia. Monitor coagulation profile (PT/INR) in high-risk patients (elderly, malnourished, hepatic/renal impaired).

Dosage: (CEFOPERZ IV/IM 2000 MG):

1. Standard adult dose: 2g every 12 hours
2. Severe/life-threatening infections: Up to 4g every 12 hours (max 8g/day)
3. Hepatic impairment: Reduce dose if bilirubin >4 mg/dL or in biliary obstruction
4. Renal impairment: No adjustment needed unless combined with nephrotoxic agents
5. Always base therapy on culture sensitivity and clinical response.

Who It’s For (CEFOPERZ IV/IM 2000 MG):

Hospitalized adults and adolescents with serious bacterial infections requiring high-dose parenteral cephalosporin therapy. Not for outpatient, mild, or viral infections. Use only under strict medical supervision in clinical settings.

Warnings & Precautions:

Cefoperazone may induce vitamin K-dependent hypoprothrombinemia—prophylactic vitamin K is recommended in at-risk patients. Avoid alcohol during treatment and for 5 days after (risk of disulfiram-like reaction: flushing, tachycardia, nausea). Monitor CBC, LFTs, and coagulation parameters during prolonged therapy (>7 days).

Drug Interactions:

1. Alcohol: Disulfiram-like reaction (avoid completely)
2. Warfarin/Anticoagulants: Increased bleeding risk—monitor INR closely
3. Aminoglycosides: Synergistic but higher nephrotoxicity risk
4. Probenecid: May increase cefoperazone serum levels
5. Always review full medication list before administration.

Additional Information:

Store below 25°C in a dry place, protected from light. Reconstituted solution is stable for 24 hours at room temperature or 72 hours refrigerated. Discard if cloudy, discolored, or contains particles. Available by prescription only in Pakistan.