Product Information:

CEFOPERZ IV/IM 1000mg is a sterile powder for injection containing Cefoperazone Sodium as the active ingredient, a third-generation cephalosporin antibiotic with broad-spectrum activity against Gram-positive and Gram-negative bacteria, including Pseudomonas aeruginosa. It works by inhibiting bacterial cell wall synthesis. CEFOPERZ is formulated for intravenous (IV) or intramuscular (IM) administration and is commonly used in hospital settings for moderate to severe systemic infections when oral therapy is not feasible.

Uses of (CEFOPERZ IV/IM 1000 MG):

1. Treatment of lower respiratory tract infections (e.g., pneumonia, bronchitis)
2. Management of urinary tract infections (including pyelonephritis)
3. Intra-abdominal infections (e.g., peritonitis, cholecystitis)
4. Skin and soft tissue infections, bone and joint infections
5. Septicemia and gynecological infections
6. Empirical therapy in febrile neutropenia (often combined with an aminoglycoside)

Key Benefits of (CEFOPERZ IV/IM 1000 MG):

1. Potent activity against Pseudomonas and other resistant Gram-negative pathogens
2. Dual excretion via bile and urine—ideal for hepatobiliary and urinary infections
3. Suitable for both IV bolus/infusion and deep IM injection
4. Often used in combination with sulbactam (though this formulation contains cefoperazone alone)
5. Effective in polymicrobial infections

How To Use (CEFOPERZ IV/IM 1000 MG):

Reconstitute the vial with appropriate diluent (e.g., sterile water, 0.9% NaCl, or lidocaine for IM use).

1. IV route: Inject slowly over 3–5 minutes or infuse over 30 minutes in 100mL compatible solution.
2. IM route: Administer as a deep intramuscular injection (use lidocaine to reduce pain).
3. Usual adult dose: 1–2 grams every 12 hours, adjusted based on infection severity and renal/hepatic function. Always follow hospital protocol and infectious disease guidance.

When Not to Use (CEFOPERZ IV/IM 1000 MG):

Do not use in patients with known hypersensitivity to cefoperazone, other cephalosporins, or penicillins (especially anaphylaxis). Avoid in neonates with hyperbilirubinemia (cefoperazone can displace bilirubin from albumin). Contraindicated in patients with severe bleeding disorders unless vitamin K is co-administered (cefoperazone may cause hypoprothrombinemia).

Side Effects of (CEFOPERZ IV/IM 1000 MG):

Common: Pain at injection site (IM), diarrhea, nausea, rash, elevated liver enzymes.

Serious (rare): Hypoprothrombinemia with bleeding (due to vitamin K deficiency), Clostridioides difficile colitis, allergic reactions (anaphylaxis), neutropenia, or transient eosinophilia. Monitor coagulation parameters in high-risk patients.

Dosage: (CEFOPERZ IV/IM 1000 MG):

1. Standard adult dose: 1–2 g every 12 hours
2. Severe infections: Up to 4 g/day in divided doses
3. Renal impairment: No dose adjustment needed alone, but if combined with nephrotoxic drugs, monitor closely
4. Hepatic impairment: Reduce dose if bilirubin >4 mg/dL or in biliary obstruction
5. Always individualize therapy based on culture results and clinical response.

Who It’s For (CEFOPERZ IV/IM 1000 MG):

Hospitalized adults and adolescents with moderate to severe bacterial infections requiring parenteral antibiotic therapy. Not for outpatient or mild infections. Use only under medical supervision in clinical settings.

Warnings & Precautions:

Cefoperazone may cause hypoprothrombinemia—administer vitamin K prophylactically in malnourished, elderly, or renal/hepatic impaired patients. Avoid alcohol during and up to 5 days after treatment (disulfiram-like reaction possible). Monitor CBC, LFTs, and coagulation profile during prolonged therapy.

Drug Interactions:

Alcohol → disulfiram-like reaction (flushing, tachycardia).

Aminoglycosides → synergistic but increased nephrotoxicity risk.

Anticoagulants (warfarin) → enhanced bleeding risk due to vitamin K antagonism.

Probenecid may increase cefoperazone levels. Always review concomitant medications.

Additional Information:

Store below 25°C in a dry place. Protect from light. Reconstituted solution is stable for 24 hours at room temperature or 72 hours refrigerated. Discard if cloudy or discolored. Available by prescription only in Pakistan.