Product Information:

BRIVAGET Ampoule 50mg/5mL contains Brivaracetam as the active ingredient, a novel antiepileptic drug that acts as a high-affinity synaptic vesicle protein 2A (SV2A) ligand. It modulates neurotransmitter release and stabilizes neuronal hyperexcitability, thereby reducing seizure frequency. BRIVAGET is formulated as a clear, sterile solution for intravenous (IV) administration, primarily used when oral therapy is temporarily not feasible in patients with partial-onset seizures.

Uses of (BRIVAGET AMP 50MG 5ML):

1. Adjunctive treatment of partial-onset (focal) seizures in adults and adolescents aged 16 years and older.
2. Short-term IV use during acute illness, surgery, or when oral intake is compromised in patients already stabilized on oral brivaracetam.
3. Not indicated for generalized seizures or as monotherapy without prior oral exposure.

Key Benefits of (BRIVAGET AMP 50MG 5ML):

1. Rapid onset of action when administered intravenously
2. High affinity for SV2A with improved tolerability vs. older antiepileptics
3. Low potential for drug interactions due to minimal hepatic metabolism
4. Seamless transition between IV and oral formulations
5. Well-tolerated with low sedation risk

How To Use (BRIVAGET AMP 50MG 5ML):

Administer by slow intravenous injection over 2–5 minutes or as an IV infusion diluted in 0.9% NaCl or 5% dextrose. The recommended dose is 50mg twice daily, consistent with the patient’s established oral regimen. Do not mix with other drugs in the same infusion line. Use only under medical supervision in a clinical setting.

When Not to Use (BRIVAGET AMP 50MG 5ML):

Do not use in patients with known hypersensitivity to brivaracetam or any excipients (e.g., sodium acetate, glacial acetic acid, water for injection). Avoid as first-line therapy or in absence of prior oral brivaracetam use. Not approved for children under 16 or for status epilepticus.

Side Effects of (BRIVAGET AMP 50MG 5ML):

Common: Dizziness, somnolence, fatigue, nausea, and headache.

Serious (rare): Psychiatric symptoms (e.g., anxiety, irritability, depression, suicidal ideation), hypersensitivity reactions, or coordination disturbances. Monitor closely for mood or behavioral changes—discontinue if severe neuropsychiatric effects occur.

Dosage: (BRIVAGET AMP 50MG 5ML):

Standard adult dose: 50mg IV twice daily.

Dose adjustments may be needed in severe hepatic impairment (Child-Pugh C: max 25mg twice daily). No renal dose adjustment required. IV formulation should match the total daily oral dose.

Who It’s For (BRIVAGET AMP 50MG 5ML):

Adults and adolescents (≥16 years) with partial-onset epilepsy who require temporary parenteral antiepileptic coverage due to inability to take oral medication. Must already be on a stable brivaracetam regimen.

Warnings & Precautions:

Brivaracetam may impair driving or operating machinery—assess individual response. Use cautiously in patients with history of psychiatric disorders. Sudden withdrawal may precipitate seizures; taper gradually if discontinuing. Inform all healthcare providers about epilepsy treatment.

Drug Interactions:

Minimal interaction potential—brivaracetam is not a significant CYP450 inducer/inhibitor. However, it may interact with rifampin (↓ brivaracetam levels) or CNS depressants (additive sedation). Always review concomitant medications.

Additional Information:

Store below 30°C, protected from light. Do not freeze. Discard if solution is discolored or contains particles. Single-use ampoule—discard unused portion. Available by prescription only in Pakistan.