Product Information:

ARTHEGET EZ 80/480mg Tablets is a fixed-dose combination containing Etoricoxib 80mg and Thiocolchicoside 4mg—note: the “480mg” appears to be a typographical or labeling error, as Thiocolchicoside is not used in doses exceeding 8mg, and standard formulations pair Etoricoxib 60mg or 80mg with Thiocolchicoside 4mg. This dual-action therapy provides potent anti-inflammatory and muscle relaxant effects for acute musculoskeletal conditions. Etoricoxib selectively inhibits COX-2 to reduce pain and swelling, while Thiocolchicoside acts on the central nervous system to relieve muscle spasm and stiffness.

Uses of (ARTHEGET EZ 80/480 MG TABS):

ARTHEGET EZ is indicated for short-term management of acute pain and inflammation in osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute gout, and severe low back pain with associated muscle spasm. It is especially useful when both joint inflammation and muscular rigidity coexist.

Key Benefits of (ARTHEGET EZ 80/480 MG TABS):

1. High-potency COX-2 inhibition for severe inflammatory pain
2. Central muscle relaxation enhances mobility and comfort
3. Once-daily dosing improves treatment adherence
4. Lower gastrointestinal risk compared to traditional NSAIDs
5. Rapid onset of action within hours of administration

How To Use (ARTHEGET EZ 80/480 MG TABS):

Take one tablet once daily, preferably with or after a meal to reduce gastric irritation. Swallow whole with water—do not crush, chew, or split. Limit use to 3–7 days for acute episodes unless specifically directed by a physician. Do not use for chronic pain without specialist supervision.

When Not to Use (ARTHEGET EZ 80/480 MG TABS):

Avoid if you have hypersensitivity to etoricoxib, thiocolchicoside, or any excipients. Contraindicated in patients with active peptic ulcers, severe heart failure, ischemic heart disease, stroke history, uncontrolled hypertension, inflammatory bowel disease, or asthma triggered by NSAIDs. Do not use during pregnancy (especially third trimester), breastfeeding, or in patients under 16 years of age.

Side Effects of (ARTHEGET EZ 80/480 MG TABS):

Common: Headache, dizziness, nausea, abdominal discomfort, mild drowsiness, or insomnia.

Serious (rare): Gastrointestinal bleeding, fluid retention, elevated liver enzymes, hypertension, severe skin reactions (e.g., Stevens-Johnson syndrome), or seizures. Discontinue immediately and seek medical help if you experience chest pain, black/tarry stools, jaundice, or unexplained fatigue.

Dosage: (ARTHEGET EZ 80/480 MG TABS):

Standard adult dose: One tablet (Etoricoxib 80mg + Thiocolchicoside 4mg) once daily.

Not recommended for more than 7 consecutive days in acute settings. Elderly patients or those with cardiovascular risk should use the lowest effective dose for the shortest duration.

Who It’s For (ARTHEGET EZ 80/480 MG TABS):

Adults aged 18–75 with moderate to severe acute musculoskeletal pain involving inflammation and muscle spasm. Not suitable for elderly patients with renal/hepatic impairment, heart disease, or those on anticoagulants without close monitoring.

Warnings & Precautions:

Etoricoxib may increase the risk of thrombotic cardiovascular events. Thiocolchicoside can cause CNS depression—avoid alcohol and operating heavy machinery. Use cautiously in patients with epilepsy, liver dysfunction, or fluid retention. Regular monitoring of blood pressure and renal function is advised during use.

Drug Interactions:

Etoricoxib may reduce the efficacy of ACE inhibitors, ARBs, and diuretics; increase lithium or methotrexate levels. Thiocolchicoside may potentiate sedation with benzodiazepines, opioids, or alcohol. Avoid concurrent use with other NSAIDs, corticosteroids, or anticoagulants.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use beyond the expiry date on the blister pack. Available by prescription only in Pakistan.